NUDT12 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NUDT12 at tissue level.

III. Associated gene sets

GO_0006734Biological processNADH metabolic process
GO_0006402Biological processmRNA catabolic process
GO_0034356Biological processNAD biosynthesis via nicotinamide riboside salvage pathway
GO_0110156Biological processmRNA methylguanosine-cap decapping
GO_0032922Biological processcircadian regulation of gene expression
GO_0006742Biological processNADP catabolic process
GO_0019677Biological processNAD catabolic process
GO_0110155Biological processNAD-cap decapping
GO_0005777Cellular componentperoxisome
GO_0005782Cellular componentperoxisomal matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990174Molecular functionphosphodiesterase decapping endonuclease activity
GO_0110153Molecular functionRNA NAD-cap (NMN-forming) hydrolase activity
GO_0000210Molecular functionNAD+ diphosphatase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding
GO_0035529Molecular functionNADH pyrophosphatase activity

IV. Literature review

[source]
Gene nameNUDT12
Protein nameNAD-capped RNA hydrolase NUDT12 (DeNADding enzyme NUDT12) (EC 3.6.1.-) (NADH pyrophosphatase NUDT12) (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12)
Synonyms
DescriptionFUNCTION: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA . The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay . Preferentially acts on NAD-capped transcripts in response to nutrient stress . Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP . May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle . Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity). .

AccessionsENST00000507423.1 [Q9BQG2-2]
ENST00000230792.7 [Q9BQG2-1]
Q9BQG2