NUDT15 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NUDT15 at tissue level.

III. Associated gene sets

GO_0055086Biological processnucleobase-containing small molecule metabolic process
GO_1901292Biological processnucleoside phosphate catabolic process
GO_0006195Biological processpurine nucleotide catabolic process
GO_0042178Biological processxenobiotic catabolic process
GO_0042262Biological processDNA protection
GO_0000278Biological processmitotic cell cycle
GO_0006203Biological processdGTP catabolic process
GO_0061136Biological processregulation of proteasomal protein catabolic process
GO_0000302Biological processresponse to reactive oxygen species
GO_0005829Cellular componentcytosol
GO_0008413Molecular function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO_0035539Molecular function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO_0044715Molecular function8-oxo-dGDP phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0047429Molecular functionnucleoside triphosphate diphosphatase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameNUDT15
Protein nameNucleotide triphosphate diphosphatase NUDT15 (EC 3.6.1.9) (MutT homolog 2) (MTH2) (Nucleoside diphosphate-linked moiety X motif 15) (Nudix motif 15) (Nucleoside diphosphate-linked to another moiety X hydrolase 15) (Nudix hydrolase 15)
SynonymsMTH2
DescriptionFUNCTION: May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP . Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives . Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear . Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs . May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA . Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). .

AccessionsENST00000258662.3
Q9NV35