Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 7 studies | 20% ± 5% | |
| pericyte | 6 studies | 17% ± 2% | |
| CD4-positive, alpha-beta T cell | 4 studies | 20% ± 3% | |
| endothelial cell | 4 studies | 23% ± 5% | |
| fibroblast | 4 studies | 25% ± 6% | |
| epithelial cell | 4 studies | 31% ± 14% | |
| natural killer cell | 4 studies | 17% ± 1% | |
| plasmablast | 3 studies | 39% ± 16% | |
| classical monocyte | 3 studies | 21% ± 1% | |
| conventional dendritic cell | 3 studies | 24% ± 5% | |
| non-classical monocyte | 3 studies | 23% ± 7% | |
| ciliated cell | 3 studies | 23% ± 3% | |
| macrophage | 3 studies | 21% ± 2% | |
| CD8-positive, alpha-beta T cell | 3 studies | 21% ± 2% | |
| dendritic cell | 3 studies | 30% ± 3% | |
| basal cell | 3 studies | 23% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 100% | 528.94 | 359 / 359 | 100% | 17.48 | 285 / 286 |
| skin | 100% | 897.18 | 1808 / 1809 | 100% | 17.01 | 470 / 472 |
| pancreas | 99% | 399.80 | 326 / 328 | 100% | 17.20 | 178 / 178 |
| thymus | 100% | 515.33 | 652 / 653 | 100% | 12.89 | 602 / 605 |
| uterus | 100% | 526.39 | 170 / 170 | 99% | 17.98 | 456 / 459 |
| ovary | 100% | 504.07 | 180 / 180 | 99% | 10.16 | 426 / 430 |
| intestine | 100% | 564.39 | 966 / 966 | 99% | 23.23 | 522 / 527 |
| lung | 99% | 607.71 | 575 / 578 | 100% | 14.10 | 1150 / 1155 |
| brain | 99% | 542.66 | 2614 / 2642 | 100% | 16.66 | 705 / 705 |
| liver | 100% | 571.17 | 226 / 226 | 99% | 11.19 | 401 / 406 |
| bladder | 100% | 623.14 | 21 / 21 | 99% | 18.55 | 497 / 504 |
| breast | 100% | 627.38 | 459 / 459 | 98% | 13.89 | 1101 / 1118 |
| esophagus | 100% | 516.93 | 1443 / 1445 | 98% | 8.87 | 180 / 183 |
| prostate | 100% | 599.00 | 244 / 245 | 99% | 13.12 | 495 / 502 |
| kidney | 100% | 670.53 | 89 / 89 | 97% | 9.45 | 878 / 901 |
| adrenal gland | 100% | 1734.09 | 258 / 258 | 97% | 16.93 | 223 / 230 |
| eye | 0% | 0 | 0 / 0 | 100% | 17.26 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 22.84 | 29 / 29 |
| muscle | 100% | 1468.76 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 754.38 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 16.87 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.61 | 1 / 1 |
| adipose | 100% | 642.81 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 564.35 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 967.00 | 835 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 92% | 447.30 | 856 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0018011 | Biological process | N-terminal peptidyl-alanine methylation |
| GO_0035573 | Biological process | N-terminal peptidyl-serine trimethylation |
| GO_0018016 | Biological process | N-terminal peptidyl-proline dimethylation |
| GO_0035570 | Biological process | N-terminal peptidyl-serine methylation |
| GO_0007051 | Biological process | spindle organization |
| GO_0018013 | Biological process | N-terminal peptidyl-glycine methylation |
| GO_0035572 | Biological process | N-terminal peptidyl-serine dimethylation |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0035568 | Biological process | N-terminal peptidyl-proline methylation |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0008276 | Molecular function | protein methyltransferase activity |
| GO_0042054 | Molecular function | histone methyltransferase activity |
| GO_0071885 | Molecular function | N-terminal protein N-methyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NTMT1 |
| Protein name | N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (X-Pro-Lys N-terminal protein methyltransferase 1A) N-terminal Xaa-Pro-Lys N-methyltransferase 1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed] |
| Synonyms | AD-003 METTL11A NRMT1 NRMT C9orf32 |
| Description | FUNCTION: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation . Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. . |
| Accessions | ENST00000482347.1 ENST00000372483.9 [Q9BV86-1] ENST00000459968.6 ENST00000617943.4 S4R338 ENST00000481189.1 ENST00000372481.7 [Q9BV86-2] ENST00000372480.1 [Q9BV86-1] ENST00000611055.4 [Q9BV86-1] S4R3J7 S4R344 ENST00000613644.4 [Q9BV86-1] Q9BV86 ENST00000372486.5 [Q9BV86-1] |