NTMT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018011Biological processN-terminal peptidyl-alanine methylation
GO_0035573Biological processN-terminal peptidyl-serine trimethylation
GO_0018016Biological processN-terminal peptidyl-proline dimethylation
GO_0035570Biological processN-terminal peptidyl-serine methylation
GO_0007051Biological processspindle organization
GO_0018013Biological processN-terminal peptidyl-glycine methylation
GO_0035572Biological processN-terminal peptidyl-serine dimethylation
GO_0006338Biological processchromatin remodeling
GO_0035568Biological processN-terminal peptidyl-proline methylation
GO_0007059Biological processchromosome segregation
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008276Molecular functionprotein methyltransferase activity
GO_0042054Molecular functionhistone methyltransferase activity
GO_0071885Molecular functionN-terminal protein N-methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNTMT1
Protein nameN-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (X-Pro-Lys N-terminal protein methyltransferase 1A)
N-terminal Xaa-Pro-Lys N-methyltransferase 1
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed]
SynonymsAD-003
METTL11A
NRMT1
NRMT
C9orf32
DescriptionFUNCTION: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation . Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. .

AccessionsENST00000482347.1
ENST00000372483.9 [Q9BV86-1]
ENST00000459968.6
ENST00000617943.4
S4R338
ENST00000481189.1
ENST00000372481.7 [Q9BV86-2]
ENST00000372480.1 [Q9BV86-1]
ENST00000611055.4 [Q9BV86-1]
S4R3J7
S4R344
ENST00000613644.4 [Q9BV86-1]
Q9BV86
ENST00000372486.5 [Q9BV86-1]