NTAN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007613Biological processmemory
GO_0008344Biological processadult locomotory behavior
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008418Molecular functionprotein-N-terminal asparagine amidohydrolase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNTAN1
Protein nameN-terminal asparagine amidase (Protein N-terminal asparagine amidohydrolase)
Protein N-terminal asparagine amidohydrolase (EC 3.5.1.121) (Protein NH2-terminal asparagine amidohydrolase) (PNAA) (Protein NH2-terminal asparagine deamidase) (PNAD) (Protein N-terminal Asn amidase) (Protein N-terminal asparagine amidase) (Protein NTN-amidase)
Synonyms
DescriptionFUNCTION: N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn. .

AccessionsENST00000634013.1
H3BMX8
ENST00000631580.1
ENST00000622833.4
ENST00000624579.3
ENST00000614882.2
ENST00000568320.5
ENST00000633231.1
Q96AB6
H3BPN7
ENST00000568738.1
H3BR97
ENST00000287706.8
ENST00000620176.4
H3BU50
ENST00000615632.4
ENST00000563940.1
ENST00000633749.1
A0A087X0T5
ENST00000565187.5
H3BNJ5
ENST00000566419.1