NRBF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006914Biological processautophagy
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0035032Cellular componentphosphatidylinositol 3-kinase complex, class III
GO_0005737Cellular componentcytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005776Cellular componentautophagosome
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNRBF2
Protein nameNuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR)
SynonymsCOPR
DescriptionFUNCTION: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). .; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy . Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 . May be involved in autophagosome biogenesis . May play a role in neural progenitor cell survival during differentiation (By similarity). .

AccessionsENST00000435510.6 [Q96F24-3]
ENST00000277746.11 [Q96F24-1]
Q96F24