Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 23% ± 5% | |
oligodendrocyte | 7 studies | 25% ± 8% | |
astrocyte | 6 studies | 30% ± 12% | |
glutamatergic neuron | 5 studies | 41% ± 24% | |
GABAergic neuron | 5 studies | 35% ± 21% | |
adipocyte | 5 studies | 21% ± 3% | |
epithelial cell | 4 studies | 26% ± 5% | |
fibroblast | 4 studies | 20% ± 4% | |
oligodendrocyte precursor cell | 4 studies | 30% ± 8% | |
interneuron | 4 studies | 30% ± 18% | |
microglial cell | 3 studies | 20% ± 4% | |
amacrine cell | 3 studies | 20% ± 2% | |
retinal bipolar neuron | 3 studies | 17% ± 1% | |
retinal cone cell | 3 studies | 26% ± 5% | |
ciliated cell | 3 studies | 20% ± 2% | |
rod bipolar cell | 3 studies | 18% ± 1% | |
erythrocyte | 3 studies | 32% ± 15% | |
transit amplifying cell | 3 studies | 22% ± 9% | |
neuron | 3 studies | 31% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2114.73 | 1445 / 1445 | 100% | 30.44 | 183 / 183 |
ovary | 100% | 3988.44 | 180 / 180 | 100% | 35.24 | 430 / 430 |
skin | 100% | 2610.07 | 1808 / 1809 | 100% | 33.74 | 472 / 472 |
brain | 100% | 2812.03 | 2640 / 2642 | 100% | 37.72 | 705 / 705 |
thymus | 100% | 3155.61 | 653 / 653 | 100% | 24.73 | 604 / 605 |
prostate | 100% | 3105.53 | 245 / 245 | 100% | 28.60 | 501 / 502 |
pancreas | 100% | 1480.99 | 327 / 328 | 100% | 19.93 | 178 / 178 |
adrenal gland | 100% | 3322.61 | 258 / 258 | 100% | 24.48 | 229 / 230 |
intestine | 100% | 1912.57 | 966 / 966 | 99% | 26.97 | 524 / 527 |
uterus | 100% | 3239.19 | 170 / 170 | 99% | 23.70 | 456 / 459 |
kidney | 100% | 2693.56 | 89 / 89 | 99% | 27.71 | 895 / 901 |
stomach | 100% | 1779.50 | 359 / 359 | 99% | 27.38 | 284 / 286 |
breast | 100% | 2674.48 | 459 / 459 | 99% | 31.67 | 1108 / 1118 |
lung | 100% | 2369.80 | 577 / 578 | 99% | 25.41 | 1146 / 1155 |
bladder | 100% | 2252.48 | 21 / 21 | 99% | 23.79 | 498 / 504 |
liver | 100% | 1685.88 | 226 / 226 | 98% | 14.47 | 396 / 406 |
adipose | 100% | 2593.70 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 46.14 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 26.96 | 29 / 29 |
muscle | 100% | 2438.21 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2908.82 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 20.26 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 23.54 | 1 / 1 |
peripheral blood | 100% | 6329.58 | 928 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2365.33 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 100% | 1890.22 | 857 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0048738 | Biological process | cardiac muscle tissue development |
GO_0060021 | Biological process | roof of mouth development |
GO_0003281 | Biological process | ventricular septum development |
GO_0010508 | Biological process | positive regulation of autophagy |
GO_1904262 | Biological process | negative regulation of TORC1 signaling |
GO_0035909 | Biological process | aorta morphogenesis |
GO_0034198 | Biological process | cellular response to amino acid starvation |
GO_0038202 | Biological process | TORC1 signaling |
GO_1990130 | Cellular component | GATOR1 complex |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0005515 | Molecular function | protein binding |
GO_0005096 | Molecular function | GTPase activator activity |
Gene name | NPRL3 |
Protein name | GATOR complex protein NPRL3 (Nitrogen permease regulator 3-like protein) GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA) NPR3 like, GATOR1 complex subunit |
Synonyms | Z69666.1-011 MARE CGTHBA C16orf35 |
Description | FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway . In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling . In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway . . FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. . FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. . FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. . |
Accessions | ENST00000621703.4 F8WEK7 ENST00000468260.5 Q12980 F8WDA5 A0A087WTE2 ENST00000611875.5 ENST00000456528.5 A0A087WTD0 ENST00000422814.5 A0A087WTP7 B7Z6Q0 ENST00000457916.5 ENST00000483663.5 F8WBJ1 F8WCB2 ENST00000419636.1 B1B1F5 ENST00000399953.7 ENST00000622194.4 |