NPRL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048738Biological processcardiac muscle tissue development
GO_0060021Biological processroof of mouth development
GO_0003281Biological processventricular septum development
GO_0010508Biological processpositive regulation of autophagy
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0035909Biological processaorta morphogenesis
GO_0034198Biological processcellular response to amino acid starvation
GO_0038202Biological processTORC1 signaling
GO_1990130Cellular componentGATOR1 complex
GO_0005765Cellular componentlysosomal membrane
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameNPRL3
Protein nameGATOR complex protein NPRL3 (Nitrogen permease regulator 3-like protein)
GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA)
NPR3 like, GATOR1 complex subunit
SynonymsZ69666.1-011
MARE
CGTHBA
C16orf35
DescriptionFUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway . In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling . In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway . .

FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. .

FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. .

FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. .

AccessionsENST00000621703.4
F8WEK7
ENST00000468260.5
Q12980
F8WDA5
A0A087WTE2
ENST00000611875.5
ENST00000456528.5
A0A087WTD0
ENST00000422814.5
A0A087WTP7
B7Z6Q0
ENST00000457916.5
ENST00000483663.5
F8WBJ1
F8WCB2
ENST00000419636.1
B1B1F5
ENST00000399953.7
ENST00000622194.4