Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 33 studies | 34% ± 17% | |
astrocyte | 13 studies | 47% ± 21% | |
microglial cell | 13 studies | 41% ± 16% | |
myeloid cell | 13 studies | 37% ± 17% | |
classical monocyte | 7 studies | 26% ± 10% | |
non-classical monocyte | 7 studies | 27% ± 9% | |
monocyte | 6 studies | 24% ± 5% | |
epithelial cell of proximal tubule | 5 studies | 22% ± 3% | |
alveolar macrophage | 4 studies | 31% ± 12% | |
mononuclear phagocyte | 4 studies | 26% ± 8% | |
oligodendrocyte precursor cell | 4 studies | 24% ± 6% | |
erythrocyte | 4 studies | 41% ± 11% | |
type II pneumocyte | 3 studies | 16% ± 1% | |
GABAergic neuron | 3 studies | 23% ± 8% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 23% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 2087.40 | 577 / 578 | 96% | 28.36 | 1112 / 1155 |
skin | 93% | 562.83 | 1687 / 1809 | 98% | 28.20 | 464 / 472 |
bladder | 100% | 821.19 | 21 / 21 | 91% | 13.23 | 460 / 504 |
brain | 92% | 1064.26 | 2441 / 2642 | 99% | 24.48 | 696 / 705 |
breast | 98% | 736.29 | 448 / 459 | 93% | 11.90 | 1044 / 1118 |
esophagus | 96% | 606.13 | 1382 / 1445 | 92% | 17.91 | 169 / 183 |
kidney | 98% | 2598.13 | 87 / 89 | 84% | 19.81 | 759 / 901 |
intestine | 99% | 596.47 | 952 / 966 | 79% | 7.32 | 415 / 527 |
stomach | 90% | 377.18 | 324 / 359 | 86% | 9.28 | 245 / 286 |
liver | 96% | 684.19 | 218 / 226 | 77% | 12.65 | 313 / 406 |
uterus | 78% | 261.36 | 132 / 170 | 88% | 13.45 | 402 / 459 |
thymus | 97% | 479.31 | 635 / 653 | 63% | 5.64 | 383 / 605 |
adrenal gland | 97% | 801.19 | 251 / 258 | 37% | 3.30 | 85 / 230 |
pancreas | 38% | 125.55 | 125 / 328 | 90% | 9.78 | 160 / 178 |
prostate | 89% | 385.68 | 217 / 245 | 25% | 1.58 | 128 / 502 |
ovary | 39% | 151.38 | 70 / 180 | 67% | 5.52 | 288 / 430 |
lymph node | 0% | 0 | 0 / 0 | 100% | 53.10 | 29 / 29 |
spleen | 100% | 3732.46 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 99% | 1243.16 | 1193 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 24.42 | 44 / 45 |
peripheral blood | 94% | 4943.85 | 877 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 65% | 450.53 | 867 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 64% | 6.45 | 51 / 80 |
heart | 55% | 211.00 | 477 / 861 | 0% | 0 | 0 / 0 |
muscle | 36% | 111.67 | 291 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0005975 | Biological process | carbohydrate metabolic process |
GO_0019262 | Biological process | N-acetylneuraminate catabolic process |
GO_0005829 | Cellular component | cytosol |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0008747 | Molecular function | N-acetylneuraminate lyase activity |
Gene name | NPL |
Protein name | N-acetylneuraminate lyase (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase) N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase) |
Synonyms | C1orf13 |
Description | FUNCTION: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate . It prevents sialic acids from being recycled and returning to the cell surface . Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway . Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (Probable). . |
Accessions | A0A087WZ70 ENST00000367552.6 [Q9BXD5-4] ENST00000614468.1 ENST00000367554.7 [Q9BXD5-2] ENST00000367553.6 [Q9BXD5-1] ENST00000258317.6 [Q9BXD5-1] ENST00000367555.5 [Q9BXD5-4] Q9BXD5 |