NOP2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NOP2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NOP2 at tissue level.

III. Associated gene sets

GO_0008284Biological processpositive regulation of cell population proliferation
GO_0070475Biological processrRNA base methylation
GO_0042273Biological processribosomal large subunit biogenesis
GO_0000027Biological processribosomal large subunit assembly
GO_0006364Biological processrRNA processing
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0000470Biological processmaturation of LSU-rRNA
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0009383Molecular functionrRNA (cytosine-C5-)-methyltransferase activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNOP2
Protein nameNOP2 nucleolar protein
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)
SynonymsNOL1
NSUN1
DescriptionFUNCTION: Involved in ribosomal large subunit assembly . S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable). .

AccessionsENST00000545492.5
ENST00000545915.5
F5H8G6
F5H359
ENST00000536124.5
ENST00000545200.5 [P46087-3]
ENST00000322166.10 [P46087-1]
ENST00000542867.5
ENST00000541778.5 [P46087-2]
F5H709
ENST00000399466.6 [P46087-2]
P46087
ENST00000538420.5
ENST00000537442.5 [P46087-1]
ENST00000542944.5
ENST00000540228.1
F5H5X6
F5GWB7
F5GYR3
ENST00000382421.7 [P46087-4]