NMNAT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009435Biological processNAD biosynthetic process
GO_0009165Biological processnucleotide biosynthetic process
GO_0034612Biological processresponse to tumor necrosis factor
GO_0009611Biological processresponse to wounding
GO_0030424Cellular componentaxon
GO_0043025Cellular componentneuronal cell body
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0004515Molecular functionnicotinate-nucleotide adenylyltransferase activity
GO_0000309Molecular functionnicotinamide-nucleotide adenylyltransferase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameNMNAT3
Protein nameNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 (NMN/NaMN adenylyltransferase 3) (Nicotinamide-nucleotide adenylyltransferase 3) (NMN adenylyltransferase 3) (Nicotinate-nucleotide adenylyltransferase 3) (NaMN adenylyltransferase 3) (EC 2.7.7.18) (Pyridine nucleotide adenylyltransferase 3) (PNAT-3) (EC 2.7.7.1)
tRNA-uridine aminocarboxypropyltransferase (EC 2.5.1.25)
NMNAT3 protein (Nicotinamide nucleotide adenylyltransferase 3, isoform CRA_e) (cDNA FLJ45569 fis, clone BRTHA3010469, highly similar to Nicotinamide mononucleotide adenylyltransferase 3)
Nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1) (EC 2.7.7.18)
Nicotinamide nucleotide adenylyltransferase 3
SynonymshCG_2022373
FKSG76
DescriptionFUNCTION: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. .

AccessionsENST00000296202.12 [Q96T66-1]
Q96T66
ENST00000645507.1
ENST00000514703.5
ENST00000339837.9 [Q96T66-2]
ENST00000646611.1
ENST00000511444.5
A0A2R8YE08
ENST00000642987.1
ENST00000645290.1
D6R975
A0A2R8YEU0
ENST00000647257.1
Q49AL4
ENST00000506254.5
ENST00000413939.6 [Q96T66-3]
D6REC8
A0A2R8YFG2
D6RGG8
ENST00000509291.5
A0A2R8YGL3
ENST00000643695.2
D6RGH7
D6RHV4
ENST00000704800.1 [Q96T66-1]
A0A2R8Y594
ENST00000512391.5