NLRX1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NLRX1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NLRX1 at tissue level.

III. Associated gene sets

GO_0045824Biological processnegative regulation of innate immune response
GO_0010936Biological processnegative regulation of macrophage cytokine production
GO_0050728Biological processnegative regulation of inflammatory response
GO_0039536Biological processnegative regulation of RIG-I signaling pathway
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0045087Biological processinnate immune response
GO_0032688Biological processnegative regulation of interferon-beta production
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNLRX1
Protein nameNLR family member X1 (Caterpiller protein 11.3) (CLR11.3) (Nucleotide-binding oligomerization domain protein 5) (Nucleotide-binding oligomerization domain protein 9)
NLR family member X1 (NOD9 protein, isoform CRA_c)
NLR family member X1
SynonymsNOD5
hCG_38441
NOD9
DescriptionFUNCTION: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction . Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 . Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis . Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species . Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity). .

AccessionsENST00000454811.5
ENST00000292199.6 [Q86UT6-1]
ENST00000706729.1 [Q86UT6-1]
C9JQE9
C9JLK8
ENST00000409991.5 [Q86UT6-1]
ENST00000409109.6 [Q86UT6-1]
ENST00000525863.1 [Q86UT6-2]
ENST00000706728.1
A0A9L9PX86
Q86UT6
C9J0R6
ENST00000449394.5
ENST00000474751.7
ENST00000706727.1
ENST00000422249.5
A0A9L9PXS9