NLRP2B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NLRP2B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NLRP2B at tissue level.

III. Associated gene sets

GO_0033137Biological processnegative regulation of peptidyl-serine phosphorylation
GO_0034122Biological processnegative regulation of toll-like receptor signaling pathway
GO_0045786Biological processnegative regulation of cell cycle
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_1900226Biological processnegative regulation of NLRP3 inflammasome complex assembly
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0045087Biological processinnate immune response
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus

IV. Literature review

[source]
Gene nameNLRP2B
Protein nameNLR family pyrin domain-containing protein 2B (Pyrin domain-containing protein 2-like protein POP4) (Pyrin-only protein 4)
SynonymsNOD24
POP4
CLRX.1
NLRP2P
DescriptionFUNCTION: May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at 'Ser-536', thereby inhibiting its transcriptional activity. Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity. May also play a role in cell cycle progression and apoptotic process. .

AccessionsENST00000434992.1
P0DMW2