NLRC3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NLRC3 at tissue level.

III. Associated gene sets

GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0032687Biological processnegative regulation of interferon-alpha production
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_1900226Biological processnegative regulation of NLRP3 inflammasome complex assembly
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0045824Biological processnegative regulation of innate immune response
GO_0035556Biological processintracellular signal transduction
GO_0050728Biological processnegative regulation of inflammatory response
GO_0032688Biological processnegative regulation of interferon-beta production
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0042110Biological processT cell activation
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0034451Cellular componentcentriolar satellite
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005524Molecular functionATP binding
GO_0036312Molecular functionphosphatidylinositol 3-kinase regulatory subunit binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameNLRC3
Protein nameNLRC3 (NOD3 protein, isoform CRA_c)
NLR family CARD domain containing 3 (NOD3 protein, isoform CRA_d)
NLR family CARD domain containing 3
NLR family CARD domain-containing protein 3 (CARD15-like protein) (Caterpiller protein 16.2) (CLR16.2) (NACHT, LRR and CARD domains-containing protein 3) (Nucleotide-binding oligomerization domain protein 3)
SynonymsNOD3
hCG_2036791
DescriptionFUNCTION: Negative regulator of the innate immune response . Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) . May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination . Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation . Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation . .

AccessionsENST00000359128.10 [Q7RTR2-1]
Q7RTR2
H3BLT9
ENST00000615877.4 [Q7RTR2-3]
ENST00000324659.12
ENST00000618137.1
A0A087WZ24
C3VPR7