NFE4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NFE4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NFE4 at tissue level.

III. Associated gene sets

GO_0006355Biological processregulation of DNA-templated transcription
GO_0065003Biological processprotein-containing complex assembly
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032991Cellular componentprotein-containing complex
GO_0005634Cellular componentnucleus
GO_0003712Molecular functiontranscription coregulator activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNFE4
Protein nameTranscription factor NF-E4
Synonyms
DescriptionFUNCTION: Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter. .

AccessionsQ86UQ8