NFATC2IP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001816Biological processcytokine production
GO_0016925Biological processprotein sumoylation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus

IV. Literature review

[source]
Gene nameNFATC2IP
Protein nameNFATC2-interacting protein (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)
NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)
SynonymsNIP45
DescriptionFUNCTION: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). .

AccessionsQ8NCF5
ENST00000320805.9 [Q8NCF5-1]
ENST00000564978.5
ENST00000568148.1 [Q8NCF5-3]
H3BSZ7