I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| OFF-bipolar cell | 4 studies | 36% ± 14% | |
| retinal bipolar neuron | 3 studies | 55% ± 12% | |
| rod bipolar cell | 3 studies | 31% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| OFF-bipolar cell | 4 studies | 36% ± 14% | |
| retinal bipolar neuron | 3 studies | 55% ± 12% | |
| rod bipolar cell | 3 studies | 31% ± 11% |
Insufficient scRNA-seq data for expression of NEUROD4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 28% | 23.78 | 73 / 258 | 64% | 15.41 | 148 / 230 |
| brain | 6% | 0.98 | 166 / 2642 | 28% | 1.09 | 194 / 705 |
| eye | 0% | 0 | 0 / 0 | 6% | 0.55 | 5 / 80 |
| prostate | 3% | 0.66 | 8 / 245 | 0% | 0 | 0 / 502 |
| kidney | 1% | 0.13 | 1 / 89 | 2% | 0.06 | 16 / 901 |
| stomach | 1% | 0.65 | 5 / 359 | 1% | 0.04 | 4 / 286 |
| breast | 0% | 0.02 | 1 / 459 | 2% | 0.20 | 17 / 1118 |
| pancreas | 0% | 0.03 | 1 / 328 | 1% | 0.05 | 2 / 178 |
| esophagus | 1% | 0.14 | 8 / 1445 | 1% | 0.07 | 1 / 183 |
| bladder | 0% | 0 | 0 / 21 | 1% | 0.24 | 5 / 504 |
| skin | 1% | 0.54 | 13 / 1809 | 0% | 0.01 | 1 / 472 |
| liver | 1% | 0.26 | 2 / 226 | 0% | 0 | 0 / 406 |
| peripheral blood | 1% | 0.07 | 8 / 929 | 0% | 0 | 0 / 0 |
| spleen | 1% | 0.08 | 2 / 241 | 0% | 0 | 0 / 0 |
| intestine | 0% | 0.05 | 4 / 966 | 0% | 0.03 | 2 / 527 |
| lung | 0% | 0.07 | 1 / 578 | 0% | 0.11 | 5 / 1155 |
| ovary | 1% | 0.07 | 1 / 180 | 0% | 0 | 0 / 430 |
| thymus | 0% | 0.15 | 3 / 653 | 0% | 0 | 0 / 605 |
| uterus | 0% | 0 | 0 / 170 | 0% | 0.02 | 2 / 459 |
| adipose | 0% | 0.40 | 3 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.03 | 2 / 803 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.03 | 2 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0.07 | 3 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0043010 | Biological process | camera-type eye development |
| GO_0045597 | Biological process | positive regulation of cell differentiation |
| GO_0045165 | Biological process | cell fate commitment |
| GO_0061564 | Biological process | axon development |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0035881 | Biological process | amacrine cell differentiation |
| GO_0097475 | Biological process | motor neuron migration |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0048709 | Biological process | oligodendrocyte differentiation |
| GO_0007405 | Biological process | neuroblast proliferation |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0070888 | Molecular function | E-box binding |
| GO_0046983 | Molecular function | protein dimerization activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Gene name | NEUROD4 |
| Protein name | Neurogenic differentiation factor 4 (NeuroD4) (Class A basic helix-loop-helix protein 4) (bHLHa4) (Protein atonal homolog 3) (ATH-3) (Atoh3) |
| Synonyms | BHLHA4 ATOH3 ATH3 |
| Description | FUNCTION: Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity). . |
| Accessions | Q9HD90 ENST00000242994.4 |
