NEURL3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NEURL3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NEURL3 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0070086Biological processubiquitin-dependent endocytosis
GO_0045087Biological processinnate immune response
GO_0005769Cellular componentearly endosome
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameNEURL3
Protein nameNeuralized E3 ubiquitin protein ligase 3
E3 ubiquitin-protein ligase NEURL3 (EC 2.3.2.27) (Lung-inducible neuralized-related C3CH4 RING domain protein) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL3)
SynonymsLINCR
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity . Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 . Inhibits also hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2 . .

AccessionsENST00000435380.3
Q96EH8
ENST00000310865.7
ENST00000451794.6
A0A087WVI2
A0A087WXE0