NELFB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048863Biological processstem cell differentiation
GO_0008283Biological processcell population proliferation
GO_0034244Biological processnegative regulation of transcription elongation by RNA polymerase II
GO_2000737Biological processnegative regulation of stem cell differentiation
GO_0032021Cellular componentNELF complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNELFB
Protein nameNegative elongation factor B
Negative elongation factor B (NELF-B) (Cofactor of BRCA1)
SynonymsKIAA1182
COBRA1
DescriptionFUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II . The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex . May be able to induce chromatin unfolding . Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity). .; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II . In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1 . .

AccessionsENST00000343053
ENST00000343053.6 [Q8WX92-2]
Q8WX92
A0A5H1ZRP4