NEK8 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NEK8 at tissue level.

III. Associated gene sets

GO_0007368Biological processdetermination of left/right symmetry
GO_0035330Biological processregulation of hippo signaling
GO_0007507Biological processheart development
GO_0009887Biological processanimal organ morphogenesis
GO_0005813Cellular componentcentrosome
GO_0005929Cellular componentcilium
GO_0097543Cellular componentciliary inversin compartment
GO_0005737Cellular componentcytoplasm
GO_0097546Cellular componentciliary base
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameNEK8
Protein nameNIMA related kinase 8
Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
SynonymsJCK
NEK12A
DescriptionFUNCTION: Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. .

AccessionsENST00000543014.1
Q86SG6
K7EMF0
ENST00000268766.11
ENST00000579671.5
K7EL04
K7END4
ENST00000592510.1
ENST00000579060.5
K7EPD3