NEK2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NEK2 at tissue level.

III. Associated gene sets

GO_1904355Biological processpositive regulation of telomere capping
GO_0000278Biological processmitotic cell cycle
GO_0007059Biological processchromosome segregation
GO_0051988Biological processregulation of attachment of spindle microtubules to kinetochore
GO_0051301Biological processcell division
GO_0090307Biological processmitotic spindle assembly
GO_0051321Biological processmeiotic cell cycle
GO_0051299Biological processcentrosome separation
GO_0051225Biological processspindle assembly
GO_0051973Biological processpositive regulation of telomerase activity
GO_0046602Biological processregulation of mitotic centrosome separation
GO_0001824Biological processblastocyst development
GO_0006468Biological processprotein phosphorylation
GO_1903126Biological processnegative regulation of centriole-centriole cohesion
GO_0046777Biological processprotein autophosphorylation
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0007088Biological processregulation of mitotic nuclear division
GO_0005730Cellular componentnucleolus
GO_0030496Cellular componentmidbody
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNEK2
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)
SynonymsNLK1
NEK2A
DescriptionFUNCTION: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly . NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis . Involved in the regulation of centrosome disjunction . Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation . .; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. .; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. .

AccessionsENST00000366998.4 [P51955-2]
ENST00000540251.5
F6U4U2
ENST00000366999.9 [P51955-1]
P51955