NEIL2 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of NEIL2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	1974.53	2642 / 2642	100%	51.62	705 / 705
skin	100%	1460.19	1809 / 1809	100%	38.72	471 / 472
thymus	100%	1401.67	653 / 653	100%	30.47	603 / 605
prostate	100%	1377.47	245 / 245	100%	26.51	500 / 502
breast	100%	1163.75	459 / 459	99%	25.36	1110 / 1118
adrenal gland	100%	2993.33	258 / 258	99%	34.57	227 / 230
ovary	100%	1273.23	180 / 180	98%	17.72	422 / 430
pancreas	98%	735.06	322 / 328	99%	20.14	177 / 178
lung	99%	934.52	575 / 578	98%	17.94	1130 / 1155
intestine	100%	894.53	964 / 966	97%	18.32	513 / 527
esophagus	100%	863.29	1445 / 1445	97%	20.32	177 / 183
kidney	100%	1038.85	89 / 89	97%	17.23	871 / 901
bladder	100%	1180.76	21 / 21	96%	15.93	483 / 504
uterus	100%	1244.21	170 / 170	96%	16.43	439 / 459
stomach	98%	653.38	352 / 359	95%	17.91	272 / 286
liver	100%	967.38	226 / 226	83%	9.33	335 / 406
adipose	100%	1106.40	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	37.17	80 / 80
lymph node	0%	0	0 / 0	100%	21.52	29 / 29
muscle	100%	1452.26	803 / 803	0%	0	0 / 0
spleen	100%	1496.84	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	7.55	1 / 1
blood vessel	100%	860.83	1331 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	14.49	44 / 45
heart	96%	1064.28	830 / 861	0%	0	0 / 0
peripheral blood	49%	392.25	455 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006284	Biological process	base-excision repair
GO_0045008	Biological process	depyrimidination
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005654	Cellular component	nucleoplasm
GO_0072686	Cellular component	mitotic spindle
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003906	Molecular function	DNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0140078	Molecular function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0019104	Molecular function	DNA N-glycosylase activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0008017	Molecular function	microtubule binding
GO_0003684	Molecular function	damaged DNA binding

Gene name	NEIL2
Protein name	Endonuclease 8-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (Endonuclease VIII-like 2) (Nei homolog 2) (NEH2) (Nei-like protein 2) NEIL2 protein Nei like DNA glycosylase 2
Synonyms
Description	FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. .
Accessions	ENST00000403422.7 [Q969S2-3] ENST00000710791.1 [Q969S2-1] Q3ZCR7 ENST00000528323.5 [Q969S2-4] ENST00000710793.1 [Q969S2-1] ENST00000710792.1 [Q969S2-3] ENST00000528113.5 ENST00000710795.1 [Q969S2-4] ENST00000455213.6 [Q969S2-1] E9PPL4 Q969S2 ENST00000710794.1 [Q969S2-1] ENST00000284503.7 [Q969S2-1] ENST00000436750.7 [Q969S2-1]

NEIL2 report