NCLN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043254Biological processregulation of protein-containing complex assembly
GO_0061635Biological processregulation of protein complex stability
GO_0009966Biological processregulation of signal transduction
GO_0003140Biological processdetermination of left/right asymmetry in lateral mesoderm
GO_1900108Biological processnegative regulation of nodal signaling pathway
GO_0050821Biological processprotein stabilization
GO_0160063Biological processmulti-pass transmembrane protein insertion into ER membrane
GO_0160064Cellular componentmulti-pass translocon complex
GO_0032991Cellular componentprotein-containing complex
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043022Molecular functionribosome binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNCLN
Protein nameBOS complex subunit NCLN (Nicalin) (Nicastrin-like protein)
BOS complex subunit NCLN (Nicalin)
Nicalin
SynonymshCG_23630
DescriptionFUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes . The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions . May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity). .

AccessionsK7EMW4
Q969V3
K7ELZ9
K7ENM2
A0A0C4DGP7
ENST00000587740.5
ENST00000590671.5
K7EQ66
ENST00000586904.1
ENST00000592737.5
ENST00000592235.1
ENST00000246117.9 [Q969V3-1]
ENST00000588428.5
K7EN96