NCKIPSD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007010Biological processcytoskeleton organization
GO_0006897Biological processendocytosis
GO_0010976Biological processpositive regulation of neuron projection development
GO_0005829Cellular componentcytosol
GO_0008180Cellular componentCOP9 signalosome
GO_0005882Cellular componentintermediate filament
GO_0008092Molecular functioncytoskeletal protein binding
GO_0005515Molecular functionprotein binding
GO_0071933Molecular functionArp2/3 complex binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameNCKIPSD
Protein nameNCK interacting protein with SH3 domain
NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein)
SynonymsAF3P21
SPIN90
DescriptionFUNCTION: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. .

AccessionsH7C2K2
ENST00000415281.1
ENST00000454134.1
ENST00000426678.1
ENST00000416649.6 [Q9NZQ3-3]
F8WCR8
ENST00000413374.1
ENST00000453349.5
H7C0T9
C9JC20
C9JMQ4
ENST00000294129.7 [Q9NZQ3-1]
Q9NZQ3
ENST00000439518.5
C9JSC3