NANOS3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NANOS3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NANOS3 at tissue level.

III. Associated gene sets

GO_0097190Biological processapoptotic signaling pathway
GO_0007283Biological processspermatogenesis
GO_0061157Biological processmRNA destabilization
GO_0006417Biological processregulation of translation
GO_0007281Biological processgerm cell development
GO_2001234Biological processnegative regulation of apoptotic signaling pathway
GO_0048477Biological processoogenesis
GO_0051726Biological processregulation of cell cycle
GO_0017148Biological processnegative regulation of translation
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0008047Molecular functionenzyme activator activity
GO_0003729Molecular functionmRNA binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNANOS3
Protein nameNanos homolog 3 (NOS-3)
SynonymsNOS3
DescriptionFUNCTION: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. .

AccessionsENST00000673200.1 [P60323-2]
ENST00000339133.6 [P60323-2]
P60323
ENST00000672749.1 [P60323-1]
ENST00000397555.3 [P60323-1]