NALCN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte	15 studies	62% ± 16%	Explore
oligodendrocyte precursor cell	14 studies	53% ± 20%	Explore
astrocyte	13 studies	39% ± 20%	Explore
glutamatergic neuron	11 studies	63% ± 23%	Explore
GABAergic neuron	10 studies	56% ± 27%	Explore
interneuron	6 studies	55% ± 35%	Explore
endothelial cell of lymphatic vessel	6 studies	28% ± 9%	Explore
neuron	5 studies	41% ± 18%	Explore
endothelial cell	5 studies	39% ± 14%	Explore
cardiac muscle cell	5 studies	26% ± 6%	Explore
GABAergic interneuron	3 studies	58% ± 8%	Explore
microglial cell	3 studies	22% ± 5%	Explore
retina horizontal cell	3 studies	35% ± 14%	Explore
retinal pigment epithelial cell	3 studies	38% ± 19%	Explore
granule cell	3 studies	54% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	48% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2402.07	2639 / 2642	93%	7.95	655 / 705
adrenal gland	59%	283.74	151 / 258	70%	6.32	160 / 230
blood vessel	98%	1578.62	1306 / 1335	0%	0	0 / 0
thymus	68%	282.44	441 / 653	23%	0.51	138 / 605
pancreas	28%	92.62	92 / 328	54%	1.41	97 / 178
heart	81%	499.42	700 / 861	0%	0	0 / 0
ovary	46%	355.28	83 / 180	3%	0.04	11 / 430
lung	37%	131.48	215 / 578	11%	0.22	128 / 1155
skin	28%	114.60	510 / 1809	17%	0.55	81 / 472
breast	25%	107.34	114 / 459	20%	0.44	227 / 1118
bladder	33%	147.43	7 / 21	4%	0.09	22 / 504
stomach	11%	31.20	38 / 359	10%	0.15	28 / 286
liver	5%	15.62	11 / 226	11%	0.25	43 / 406
adipose	13%	50.46	159 / 1204	0%	0	0 / 0
uterus	9%	29.51	15 / 170	3%	0.07	14 / 459
kidney	4%	15.47	4 / 89	7%	0.16	65 / 901
prostate	4%	17.74	11 / 245	2%	0.03	8 / 502
intestine	1%	4.24	14 / 966	4%	0.11	23 / 527
esophagus	1%	4.49	17 / 1445	3%	0.04	6 / 183
eye	0%	0	0 / 0	3%	0.07	2 / 80
tonsil	0%	0	0 / 0	2%	0.27	1 / 45
spleen	0%	1.09	1 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0032224	Biological process	positive regulation of synaptic transmission, cholinergic
GO_0032230	Biological process	positive regulation of synaptic transmission, GABAergic
GO_0060075	Biological process	regulation of resting membrane potential
GO_0071805	Biological process	potassium ion transmembrane transport
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0034702	Cellular component	monoatomic ion channel complex
GO_0005886	Cellular component	plasma membrane
GO_0022840	Molecular function	leak channel activity
GO_0005272	Molecular function	sodium channel activity
GO_0005248	Molecular function	voltage-gated sodium channel activity
GO_0005515	Molecular function	protein binding
GO_0005261	Molecular function	monoatomic cation channel activity

IV. Literature review

[source]

Gene name	NALCN
Protein name	Sodium leak channel NALCN (CanIon) (Sodium leak channel non-selective protein) (Voltage gated channel-like protein 1) NALCN protein Sodium leak channel, non-selective Sodium leak channel, non-selective (Voltage gated channel like 1, isoform CRA_b)
Synonyms	VGCNL1 hCG_1811326
Description	FUNCTION: Voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability . NALCN channel functions as a multi-protein complex, which consists at least of NALCN, NALF1, UNC79 and UNC80 . NALCN is the voltage-sensing, pore-forming subunit of the NALCN channel complex . NALCN channel complex is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations . In addition to its role in regulating neuronal excitability, is required for normal respiratory rhythm, systemic osmoregulation by controlling the serum sodium concentration and in the regulation of the intestinal pace-making activity in the interstitial cells of Cajal (By similarity). NALCN channel is also activated by neuropeptides such as neurotensin and substance P (SP) through a SRC family kinases-dependent pathway (By similarity). In addition, NALCN activity is enhanced/modulated by several GPCRs, such as CHRM3 (By similarity). .
Accessions	A0A6Q8PHH0 ENST00000648359.1 A0A6Q8PHC5 ENST00000497170.5 A0A6Q8PFS9 ENST00000251127.11 [Q8IZF0-1] ENST00000676315.1 A0A6Q8PF19 ENST00000675802.1 Q8IZF0 A0A6Q8PGX7 ENST00000675594.1 A0A976XH31 ENST00000675150.1 A0A3B3ISV8 A0A1D8QAD2 ENST00000675332.1 ENST00000467264.2 ENST00000376200.6 [Q8IZF0-3] A0A1D8QAD6 A0A6Q8PFJ2 A0A6Q8PG91

NALCN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review