NAF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043489Biological processRNA stabilization
GO_1904874Biological processpositive regulation of telomerase RNA localization to Cajal body
GO_0000493Biological processbox H/ACA snoRNP assembly
GO_0090669Biological processtelomerase RNA stabilization
GO_1905323Biological processtelomerase holoenzyme complex assembly
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0042254Biological processribosome biogenesis
GO_0051973Biological processpositive regulation of telomerase activity
GO_0000454Biological processsnoRNA guided rRNA pseudouridine synthesis
GO_1904358Biological processpositive regulation of telomere maintenance via telomere lengthening
GO_0005732Cellular componentsno(s)RNA-containing ribonucleoprotein complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0070034Molecular functiontelomerase RNA binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNAF1
Protein nameNef-associated factor 1 SNP
Nuclear assembly factor 1 ribonucleoprotein
H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1)
Synonyms
DescriptionFUNCTION: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. .

AccessionsENST00000509434.5
Q96HR8
D6RIB3
ENST00000422287.6 [Q96HR8-2]
ENST00000274054.3 [Q96HR8-1]
A4F1Y0