MXRA8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060857Biological processestablishment of glial blood-brain barrier
GO_0007155Biological processcell adhesion
GO_0030154Biological processcell differentiation
GO_0060170Cellular componentciliary membrane
GO_0009986Cellular componentcell surface
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0070062Cellular componentextracellular exosome
GO_0005923Cellular componentbicellular tight junction
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameMXRA8
Protein nameMatrix remodeling-associated protein 8 (Limitrin)
Synonyms
DescriptionFUNCTION: Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 . Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis . Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells . Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK . May play a role in the maturation and maintenance of the blood-brain barrier (By similarity). .; FUNCTION: (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses. .

AccessionsENST00000309212.11 [Q9BRK3-1]
ENST00000477278.3 [Q9BRK3-3]
ENST00000342753.8 [Q9BRK3-4]
Q9BRK3
ENST00000445648.5 [Q9BRK3-2]