MVD report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MVD at tissue level.

III. Associated gene sets

GO_0008299Biological processisoprenoid biosynthetic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0006695Biological processcholesterol biosynthetic process
GO_0019287Biological processisopentenyl diphosphate biosynthetic process, mevalonate pathway
GO_0005829Cellular componentcytosol
GO_0005777Cellular componentperoxisome
GO_0042803Molecular functionprotein homodimerization activity
GO_0004163Molecular functiondiphosphomevalonate decarboxylase activity
GO_0030544Molecular functionHsp70 protein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMVD
Protein nameDiphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase)
Mevalonate diphosphate decarboxylase
Diphosphomevalonate decarboxylase (Mevalonate (diphospho)decarboxylase) (Mevalonate pyrophosphate decarboxylase)
SynonymsMPD
DescriptionFUNCTION: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. .

FUNCTION: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. .

AccessionsENST00000565610.5
ENST00000301012.8
H3BP35
ENST00000568133.5
H3BQ47
H3BVC4
ENST00000567064.5
H3BRZ1
ENST00000569177.5
P53602