MVB12A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0039702Biological processviral budding via host ESCRT complex
GO_0036258Biological processmultivesicular body assembly
GO_0046755Biological processviral budding
GO_0016236Biological processmacroautophagy
GO_0043162Biological processubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0042058Biological processregulation of epidermal growth factor receptor signaling pathway
GO_0090148Biological processmembrane fission
GO_0032510Biological processendosome to lysosome transport via multivesicular body sorting pathway
GO_0019075Biological processvirus maturation
GO_0032801Biological processreceptor catabolic process
GO_0043328Biological processprotein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0031902Cellular componentlate endosome membrane
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0000813Cellular componentESCRT I complex
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0031982Cellular componentvesicle
GO_0005634Cellular componentnucleus
GO_0043130Molecular functionubiquitin binding
GO_0008289Molecular functionlipid binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameMVB12A
Protein nameMultivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A)
Multivesicular body subunit 12A
Multivesicular body subunit 12A (ESCRT-I complex subunit MVB12A) (Protein FAM125A)
SynonymsFAM125A
CFBP
DescriptionFUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. .

AccessionsENST00000528515.5
ENST00000594784.1
ENST00000600514.5
Q96EY5
ENST00000528911.5
E9PLL0
E9PQA6
E9PLZ8
ENST00000528604.5
M0QZK6
ENST00000529939.5
ENST00000317040.12 [Q96EY5-1]
E9PJW8