MUS81 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MUS81 at tissue level.

III. Associated gene sets

GO_0033687Biological processosteoblast proliferation
GO_0006281Biological processDNA repair
GO_0006302Biological processdouble-strand break repair
GO_0006308Biological processDNA catabolic process
GO_0000727Biological processdouble-strand break repair via break-induced replication
GO_0031297Biological processreplication fork processing
GO_0000712Biological processresolution of meiotic recombination intermediates
GO_0031573Biological processmitotic intra-S DNA damage checkpoint signaling
GO_0072429Biological processresponse to intra-S DNA damage checkpoint signaling
GO_0043596Cellular componentnuclear replication fork
GO_0005730Cellular componentnucleolus
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_1905347Cellular componentendodeoxyribonuclease complex
GO_0048476Cellular componentHolliday junction resolvase complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0008821Molecular functioncrossover junction DNA endonuclease activity
GO_0004519Molecular functionendonuclease activity
GO_0046872Molecular functionmetal ion binding
GO_0048257Molecular function3'-flap endonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMUS81
Protein nameMUS81 structure-specific endonuclease subunit
Crossover junction endonuclease MUS81 (EC 3.1.22.-)
SynonymshCG_23303
DescriptionFUNCTION: Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. Plays an essential role in mitosis for the processing of stalled or collapsed replication forks . .

FUNCTION: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). .

FUNCTION: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). .

FUNCTION: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). .

FUNCTION: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). .

FUNCTION: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). .

FUNCTION: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). .

FUNCTION: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). .

AccessionsE9PII7
ENST00000529742.1
ENST00000529374.5
H0YE94
ENST00000308110.9
B3KX63
H0YDE3
ENST00000525768.5
ENST00000529857.5
E9PRI1
ENST00000524647.5
H0YDU2
ENST00000533035.5
E9PL60
ENST00000530111.1
Q96NY9
H0YDK3