MTRR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046655Biological processfolic acid metabolic process
GO_1904042Biological processnegative regulation of cystathionine beta-synthase activity
GO_0009086Biological processmethionine biosynthetic process
GO_0033353Biological processS-adenosylmethionine cycle
GO_0050667Biological processhomocysteine metabolic process
GO_0043418Biological processhomocysteine catabolic process
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0071949Molecular functionFAD binding
GO_0070402Molecular functionNADPH binding
GO_0016723Molecular functionoxidoreductase activity, acting on metal ions, NAD or NADP as acceptor
GO_0030586Molecular function[methionine synthase] reductase (NADPH) activity
GO_0010181Molecular functionFMN binding
GO_0050660Molecular functionflavin adenine dinucleotide binding
GO_0005515Molecular functionprotein binding
GO_0003958Molecular functionNADPH-hemoprotein reductase activity

IV. Literature review

[source]
Gene nameMTRR
Protein nameMethionine synthase reductase (MSR) (EC 1.16.1.8) (Aquacobalamin reductase) (AqCbl reductase)
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Synonyms
DescriptionFUNCTION: Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin . Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine . Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme . Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme . .

AccessionsENST00000506877.1
A0A3P9MRF3
ENST00000510279.5
ENST00000502550.5
ENST00000514369.5
D6RF21
H0Y963
ENST00000514220.5
Q9UBK8
ENST00000264668.6 [Q9UBK8-1]
D6RAY3
ENST00000512217.5
H0Y9Q0
ENST00000510525.5
ENST00000513439.5
H0Y8S9
D6RAZ2
ENST00000511461.5
ENST00000440940.7 [Q9UBK8-2]
D6RGC7
ENST00000503550.5
D6RIS8
H0Y9D5
ENST00000508047.5