MTRES1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MTRES1 at tissue level.

III. Associated gene sets

GO_0072344Biological processrescue of stalled ribosome
GO_1903108Biological processregulation of mitochondrial transcription
GO_0005739Cellular componentmitochondrion
GO_0005759Cellular componentmitochondrial matrix
GO_0043023Molecular functionribosomal large subunit binding
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameMTRES1
Protein nameMitochondrial transcription rescue factor 1
SynonymsC6orf203
HSPC230
DescriptionFUNCTION: Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability . Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation . As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue . .

AccessionsENST00000625458.1
A0A0D9SEI0
ENST00000311381.8
Q9P0P8
ENST00000405204.6