MTPAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000965Biological processmitochondrial RNA 3'-end processing
GO_0071044Biological processhistone mRNA catabolic process
GO_0006397Biological processmRNA processing
GO_0031123Biological processRNA 3'-end processing
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0030145Molecular functionmanganese ion binding
GO_0042803Molecular functionprotein homodimerization activity
GO_1990817Molecular functionpoly(A) RNA polymerase activity
GO_0002134Molecular functionUTP binding
GO_0005524Molecular functionATP binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameMTPAP
Protein nameMitochondrial poly(A) polymerase
Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP)
SynonymsPAPD1
DescriptionFUNCTION: Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. .

AccessionsENST00000263063.9 [Q9NVV4-1]
ENST00000421701.1
Q5T852
Q9NVV4
Q5T851
ENST00000417581.1