MTMR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006470Biological processprotein dephosphorylation
GO_0031642Biological processnegative regulation of myelination
GO_2000643Biological processpositive regulation of early endosome to late endosome transport
GO_2000645Biological processnegative regulation of receptor catabolic process
GO_0045806Biological processnegative regulation of endocytosis
GO_0032288Biological processmyelin assembly
GO_0046856Biological processphosphatidylinositol dephosphorylation
GO_0048666Biological processneuron development
GO_0090394Biological processnegative regulation of excitatory postsynaptic potential
GO_0097062Biological processdendritic spine maintenance
GO_0002091Biological processnegative regulation of receptor internalization
GO_0060304Biological processregulation of phosphatidylinositol dephosphorylation
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0043197Cellular componentdendritic spine
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0097060Cellular componentsynaptic membrane
GO_0031901Cellular componentearly endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005774Cellular componentvacuolar membrane
GO_0030424Cellular componentaxon
GO_0005634Cellular componentnucleus
GO_0004438Molecular functionphosphatidylinositol-3-phosphate phosphatase activity
GO_0042802Molecular functionidentical protein binding
GO_0008138Molecular functionprotein tyrosine/serine/threonine phosphatase activity
GO_0052629Molecular functionphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMTMR2
Protein nameMyotubularin related protein 2
Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)
Myotubularin-related protein 2 (EC 3.1.3.64) (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase)
SynonymsKIAA1073
DescriptionFUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate . Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (By similarity). Stabilizes SBF2/MTMR13 at the membranes (By similarity). Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity). .

AccessionsA0A6Q8PF46
ENST00000676268.1
ENST00000676177.1
ENST00000393223.8 [Q13614-2]
ENST00000676440.1 [Q13614-2]
ENST00000675981.1 [Q13614-2]
ENST00000675636.1 [Q13614-2]
Q13614
ENST00000481642.6 [Q13614-2]
ENST00000675196.1 [Q13614-2]
ENST00000409459.5 [Q13614-2]
ENST00000676261.1 [Q13614-2]
C9JEX3
A0A6Q8PFL3
ENST00000674989.1 [Q13614-2]
ENST00000675660.1
ENST00000676388.1
ENST00000676272.1 [Q13614-2]
ENST00000674974.1
ENST00000444541.7 [Q13614-2]
ENST00000675288.1
ENST00000470293.6 [Q13614-2]
ENST00000675174.1 [Q13614-2]
ENST00000444541
ENST00000674950.1
ENST00000675910.1
ENST00000675022.1
ENST00000675652.1 [Q13614-2]
ENST00000675320.1
ENST00000676146.1
ENST00000676378.1 [Q13614-2]
ENST00000674610.1 [Q13614-2]
A0A6Q8PGV9
ENST00000675848.1
A0A6Q8PHC4
ENST00000675896.1
ENST00000674528.1 [Q13614-2]
A0A6Q8PGS5
ENST00000674924.1 [Q13614-2]
ENST00000346299.10 [Q13614-1]
ENST00000675922.1
ENST00000675362.1 [Q13614-2]
ENST00000495134.6 [Q13614-2]
A0A6Q8PHL9
ENST00000675030.1
ENST00000675933.1 [Q13614-2]
ENST00000497683.6 [Q13614-2]
A0A6Q8PG25
ENST00000675489.1 [Q13614-2]
ENST00000484818.6 [Q13614-2]
ENST00000674968.1 [Q13614-2]
ENST00000675454.1 [Q13614-2]
ENST00000675477.1 [Q13614-2]
ENST00000676027.1
ENST00000675438.1
A0A6Q8PGT1
A0A6Q8PHS7
ENST00000352297.11 [Q13614-2]
ENST00000675807.1
ENST00000676166.1 [Q13614-2]