Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 9 studies | 22% ± 5% | |
| astrocyte | 9 studies | 32% ± 17% | |
| epithelial cell | 7 studies | 31% ± 17% | |
| oligodendrocyte | 7 studies | 29% ± 10% | |
| glutamatergic neuron | 5 studies | 42% ± 20% | |
| oligodendrocyte precursor cell | 5 studies | 29% ± 9% | |
| ciliated cell | 4 studies | 31% ± 12% | |
| luminal hormone-sensing cell of mammary gland | 4 studies | 19% ± 3% | |
| type II pneumocyte | 4 studies | 25% ± 10% | |
| basal cell | 4 studies | 28% ± 1% | |
| B cell | 3 studies | 16% ± 0% | |
| microglial cell | 3 studies | 17% ± 2% | |
| hepatocyte | 3 studies | 54% ± 16% | |
| macrophage | 3 studies | 17% ± 1% | |
| GABAergic neuron | 3 studies | 49% ± 3% | |
| platelet | 3 studies | 18% ± 3% | |
| interneuron | 3 studies | 43% ± 18% | |
| neuron | 3 studies | 26% ± 8% | |
| plasmacytoid dendritic cell | 3 studies | 21% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 1001.75 | 245 / 245 | 100% | 8.60 | 502 / 502 |
| brain | 100% | 598.10 | 2639 / 2642 | 100% | 6.24 | 704 / 705 |
| thymus | 100% | 1137.35 | 653 / 653 | 100% | 5.65 | 602 / 605 |
| esophagus | 100% | 653.24 | 1445 / 1445 | 99% | 3.63 | 182 / 183 |
| breast | 100% | 783.50 | 459 / 459 | 99% | 4.07 | 1111 / 1118 |
| ovary | 100% | 727.41 | 180 / 180 | 99% | 3.85 | 425 / 430 |
| lung | 99% | 602.39 | 575 / 578 | 99% | 3.43 | 1139 / 1155 |
| adrenal gland | 100% | 848.80 | 258 / 258 | 98% | 3.59 | 225 / 230 |
| pancreas | 100% | 465.42 | 327 / 328 | 96% | 2.33 | 171 / 178 |
| bladder | 100% | 526.19 | 21 / 21 | 96% | 2.93 | 482 / 504 |
| uterus | 99% | 647.78 | 169 / 170 | 96% | 3.15 | 441 / 459 |
| intestine | 100% | 697.21 | 966 / 966 | 95% | 2.83 | 500 / 527 |
| stomach | 100% | 609.00 | 359 / 359 | 94% | 2.82 | 269 / 286 |
| kidney | 100% | 708.78 | 89 / 89 | 92% | 2.18 | 829 / 901 |
| skin | 100% | 639.33 | 1806 / 1809 | 84% | 2.26 | 398 / 472 |
| liver | 100% | 1251.76 | 226 / 226 | 78% | 1.89 | 317 / 406 |
| spleen | 100% | 666.46 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.09 | 1 / 1 |
| blood vessel | 100% | 640.11 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 465.69 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 533.01 | 800 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 447.66 | 846 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 2.01 | 39 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 1.89 | 25 / 29 |
| eye | 0% | 0 | 0 / 0 | 44% | 0.85 | 35 / 80 |
| peripheral blood | 37% | 164.10 | 348 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0046655 | Biological process | folic acid metabolic process |
| GO_0006164 | Biological process | purine nucleotide biosynthetic process |
| GO_0000105 | Biological process | L-histidine biosynthetic process |
| GO_0009086 | Biological process | methionine biosynthetic process |
| GO_0035999 | Biological process | tetrahydrofolate interconversion |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0004477 | Molecular function | methenyltetrahydrofolate cyclohydrolase activity |
| GO_0004487 | Molecular function | methylenetetrahydrofolate dehydrogenase (NAD+) activity |
| GO_0004488 | Molecular function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| Gene name | MTHFD2L |
| Protein name | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like MTHFD2L protein (Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like) Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein) (MTHFD2-like) [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15) (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] |
| Synonyms | |
| Description | FUNCTION: Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. . |
| Accessions | Q8IY64 F8W7P9 ENST00000325278.7 [Q9H903-4] ENST00000395759.6 [Q9H903-4] ENST00000359107.10 Q9H903 ENST00000423607.6 ENST00000429335.5 |