MSRB1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MSRB1 at tissue level.

III. Associated gene sets

GO_0030041Biological processactin filament polymerization
GO_0030091Biological processprotein repair
GO_0045087Biological processinnate immune response
GO_0005575Cellular componentcellular_component
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0033745Molecular functionL-methionine-(R)-S-oxide reductase activity
GO_0033743Molecular functionpeptide-methionine (R)-S-oxide reductase activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameMSRB1
Protein nameMethionine-R-sulfoxide reductase B1 (MsrB1) (EC 1.8.4.12) (EC 1.8.4.14) (Selenoprotein X) (SelX)
Methionine sulfoxide reductase B1
Methionine-R-sulfoxide reductase B1 (EC 1.8.4.12) (EC 1.8.4.14) (Selenoprotein X)
SynonymsHSPC270
SEPX1
DescriptionFUNCTION: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. .

AccessionsENST00000399753.2
A8MYR2
Q9NZV6
H3BTT6
ENST00000564908.1
ENST00000361871.8
ENST00000709225.1
ENST00000473663.1
H3BS64