MSL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006338Biological processchromatin remodeling
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0072487Cellular componentMSL complex
GO_0005634Cellular componentnucleus
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameMSL1
Protein nameMale-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1)
MSL complex subunit 1
SynonymsMSL1L1
DescriptionFUNCTION: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure . Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) . This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 . In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation . .

AccessionsENST00000398532.9 [Q68DK7-1]
J3KRQ4
ENST00000582884.5
J3QQY0
ENST00000582920.1
ENST00000579565.5 [Q68DK7-3]
J3KTC2
Q68DK7
ENST00000577454.5
J3KSZ8
ENST00000578648.5