MREG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030318Biological processmelanocyte differentiation
GO_0032400Biological processmelanosome localization
GO_0090382Biological processphagosome maturation
GO_0032402Biological processmelanosome transport
GO_0072385Biological processminus-end-directed organelle transport along microtubule
GO_0042470Cellular componentmelanosome
GO_0016324Cellular componentapical plasma membrane
GO_0033162Cellular componentmelanosome membrane
GO_0032991Cellular componentprotein-containing complex
GO_0031090Cellular componentorganelle membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005515Molecular functionprotein binding
GO_0035091Molecular functionphosphatidylinositol binding

IV. Literature review

[source]
Gene nameMREG
Protein nameMelanoregulin (Dilute suppressor protein homolog)
Melanoregulin
SynonymsDSU
HDCGA21P
DescriptionFUNCTION: Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells . Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity). .

AccessionsC9JFU1
C9JAG4
ENST00000439791.5
ENST00000424992.5
Q8N565
ENST00000420348.1
C9JYV9
ENST00000263268.11 [Q8N565-1]