MPEG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0002250Biological processadaptive immune response
GO_0140367Biological processantibacterial innate immune response
GO_0002478Biological processantigen processing and presentation of exogenous peptide antigen
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0002468Biological processdendritic cell antigen processing and presentation
GO_0055085Biological processtransmembrane transport
GO_0042742Biological processdefense response to bacterium
GO_0042590Biological processantigen processing and presentation of exogenous peptide antigen via MHC class I
GO_0061474Cellular componentphagolysosome membrane
GO_0045335Cellular componentphagocytic vesicle
GO_0005576Cellular componentextracellular region
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0022829Molecular functionwide pore channel activity

IV. Literature review

[source]
Gene nameMPEG1
Protein nameMacrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form]
Synonyms
DescriptionFUNCTION: Pore-forming protein involved in both innate and adaptive immunity . Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation (By similarity). Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria . Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity). .; FUNCTION: [Macrophage-expressed gene 1 protein, processed form]: Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation (By similarity). Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells (By similarity). Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming (By similarity). .

AccessionsQ2M385
ENST00000361050.4 [Q2M385-1]