Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 30 studies | 39% ± 19% | |
classical monocyte | 27 studies | 50% ± 17% | |
non-classical monocyte | 25 studies | 46% ± 15% | |
plasmacytoid dendritic cell | 24 studies | 61% ± 16% | |
conventional dendritic cell | 23 studies | 35% ± 13% | |
monocyte | 20 studies | 38% ± 14% | |
dendritic cell | 11 studies | 40% ± 18% | |
myeloid cell | 9 studies | 35% ± 13% | |
neutrophil | 5 studies | 38% ± 7% | |
mononuclear phagocyte | 4 studies | 59% ± 15% | |
intermediate monocyte | 4 studies | 56% ± 20% | |
leukocyte | 3 studies | 29% ± 10% | |
memory B cell | 3 studies | 20% ± 4% | |
tissue-resident macrophage | 3 studies | 38% ± 20% | |
inflammatory macrophage | 3 studies | 36% ± 5% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 10 studies | 25% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 98% | 2903.06 | 565 / 578 | 90% | 30.45 | 1044 / 1155 |
breast | 85% | 1430.64 | 389 / 459 | 92% | 30.36 | 1027 / 1118 |
intestine | 92% | 2443.58 | 889 / 966 | 77% | 20.07 | 404 / 527 |
bladder | 86% | 996.38 | 18 / 21 | 64% | 16.61 | 321 / 504 |
adrenal gland | 90% | 1570.69 | 232 / 258 | 56% | 9.62 | 129 / 230 |
stomach | 62% | 645.82 | 222 / 359 | 83% | 29.31 | 237 / 286 |
prostate | 66% | 608.83 | 161 / 245 | 76% | 14.13 | 382 / 502 |
thymus | 67% | 820.36 | 435 / 653 | 71% | 15.97 | 430 / 605 |
esophagus | 63% | 730.19 | 915 / 1445 | 72% | 13.77 | 132 / 183 |
kidney | 42% | 588.60 | 37 / 89 | 86% | 36.68 | 778 / 901 |
liver | 41% | 490.34 | 93 / 226 | 76% | 14.13 | 307 / 406 |
skin | 29% | 221.44 | 522 / 1809 | 84% | 34.64 | 398 / 472 |
uterus | 45% | 404.60 | 76 / 170 | 62% | 11.36 | 285 / 459 |
pancreas | 21% | 143.10 | 68 / 328 | 80% | 22.12 | 142 / 178 |
lymph node | 0% | 0 | 0 / 0 | 100% | 202.06 | 29 / 29 |
spleen | 100% | 22073.08 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 9637.99 | 920 / 929 | 0% | 0 | 0 / 0 |
ovary | 28% | 268.14 | 51 / 180 | 70% | 14.16 | 299 / 430 |
adipose | 97% | 3126.30 | 1162 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 87% | 27.90 | 39 / 45 |
brain | 11% | 78.42 | 291 / 2642 | 71% | 12.47 | 500 / 705 |
blood vessel | 65% | 1204.87 | 865 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 55% | 10.75 | 44 / 80 |
heart | 45% | 451.51 | 387 / 861 | 0% | 0 | 0 / 0 |
muscle | 8% | 48.09 | 61 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0050829 | Biological process | defense response to Gram-negative bacterium |
GO_0002250 | Biological process | adaptive immune response |
GO_0140367 | Biological process | antibacterial innate immune response |
GO_0002478 | Biological process | antigen processing and presentation of exogenous peptide antigen |
GO_0050830 | Biological process | defense response to Gram-positive bacterium |
GO_0002468 | Biological process | dendritic cell antigen processing and presentation |
GO_0055085 | Biological process | transmembrane transport |
GO_0042742 | Biological process | defense response to bacterium |
GO_0042590 | Biological process | antigen processing and presentation of exogenous peptide antigen via MHC class I |
GO_0061474 | Cellular component | phagolysosome membrane |
GO_0045335 | Cellular component | phagocytic vesicle |
GO_0005576 | Cellular component | extracellular region |
GO_0030670 | Cellular component | phagocytic vesicle membrane |
GO_0031410 | Cellular component | cytoplasmic vesicle |
GO_0022829 | Molecular function | wide pore channel activity |
Gene name | MPEG1 |
Protein name | Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form] |
Synonyms | |
Description | FUNCTION: Pore-forming protein involved in both innate and adaptive immunity . Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation (By similarity). Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria . Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity). .; FUNCTION: [Macrophage-expressed gene 1 protein, processed form]: Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation (By similarity). Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells (By similarity). Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming (By similarity). . |
Accessions | Q2M385 ENST00000361050.4 [Q2M385-1] |