MOV10 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MOV10 at tissue level.

III. Associated gene sets

GO_0141008Biological processretrotransposon silencing by mRNA destabilization
GO_0035279Biological processmiRNA-mediated gene silencing by mRNA destabilization
GO_0051607Biological processdefense response to virus
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0010526Biological processretrotransposon silencing
GO_0035195Biological processmiRNA-mediated post-transcriptional gene silencing
GO_0035194Biological processregulatory ncRNA-mediated post-transcriptional gene silencing
GO_0150011Biological processregulation of neuron projection arborization
GO_0061014Biological processpositive regulation of mRNA catabolic process
GO_0005615Cellular componentextracellular space
GO_0043186Cellular componentP granule
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0032574Molecular function5'-3' RNA helicase activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameMOV10
Protein nameMov10 RISC complex RNA helicase
Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein)
RNA helicase (EC 3.6.4.13)
SynonymsKIAA1631
hCG_38463
DescriptionFUNCTION: 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission . Plays an important role in innate antiviral immunity by promoting type I interferon production . Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation . Blocks HIV-1 virus replication at a post-entry step . Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway . Inhibits also hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription . Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs . Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC . In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 . Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 . Facilitates LINE-1 uridylation by TUT4 and TUT7 . Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor . .; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. .

AccessionsENST00000686923.1
ENST00000369644.5
ENST00000686428.1
A0A8I5KZ07
ENST00000357443.2 [Q9HCE1-1]
A0A8I5QKW4
ENST00000686097.1
Q5JR04
ENST00000369645.6 [Q9HCE1-1]
ENST00000413052.6 [Q9HCE1-1]
Q9HCE1
A0A8I5KXC3