MORN3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MORN3 at tissue level.

III. Associated gene sets

GO_1901797Biological processnegative regulation of signal transduction by p53 class mediator
GO_0001669Cellular componentacrosomal vesicle
GO_0005634Cellular componentnucleus
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMORN3
Protein nameMORN repeat-containing protein 3
Synonyms
DescriptionFUNCTION: Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors . May play a role in the regulation of spermatogenesis (By similarity). .

AccessionsENST00000392462.6 [Q6PF18-2]
ENST00000355329.7 [Q6PF18-1]
ENST00000542364.1 [Q6PF18-2]
Q6PF18