MMP3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MMP3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MMP3 at tissue level.

III. Associated gene sets

GO_0034614Biological processcellular response to reactive oxygen species
GO_0150077Biological processregulation of neuroinflammatory response
GO_0045087Biological processinnate immune response
GO_0030198Biological processextracellular matrix organization
GO_0022617Biological processextracellular matrix disassembly
GO_1904645Biological processresponse to amyloid-beta
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_0071732Biological processcellular response to nitric oxide
GO_0030574Biological processcollagen catabolic process
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0030334Biological processregulation of cell migration
GO_0006508Biological processproteolysis
GO_0071230Biological processcellular response to amino acid stimulus
GO_0030163Biological processprotein catabolic process
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0071492Biological processcellular response to UV-A
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005739Cellular componentmitochondrion
GO_0031012Cellular componentextracellular matrix
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0008233Molecular functionpeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0008237Molecular functionmetallopeptidase activity
GO_0008270Molecular functionzinc ion binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameMMP3
Protein nameMMP3
Matrix metallopeptidase 3
Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1)
Matrix metalloproteinase 3
SynonymsSTMY1
DescriptionFUNCTION: Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9 . Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway . Acts also intracellularly . For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage . In addition, plays a role in immune response and possesses antiviral activity against various viruses such as vesicular stomatitis virus, influenza A virus (H1N1) and human herpes virus 1 . Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities . .

AccessionsENST00000299855.10
A0A0U3J4I2
ENST00000524478.1
E9PKX2
P08254
H7C139
A5GZ70
ENST00000434103.1