MMP16 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0001501Biological processskeletal system development
GO_0097094Biological processcraniofacial suture morphogenesis
GO_0016485Biological processprotein processing
GO_0030198Biological processextracellular matrix organization
GO_0035988Biological processchondrocyte proliferation
GO_0030574Biological processcollagen catabolic process
GO_0001958Biological processendochondral ossification
GO_0006508Biological processproteolysis
GO_0005615Cellular componentextracellular space
GO_0005796Cellular componentGolgi lumen
GO_0009986Cellular componentcell surface
GO_0005886Cellular componentplasma membrane
GO_0031012Cellular componentextracellular matrix
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0008047Molecular functionenzyme activator activity
GO_0070006Molecular functionmetalloaminopeptidase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameMMP16
Protein nameMatrix metallopeptidase 16
Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)
SynonymsMMPX2
C8orf57
DescriptionFUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. .

AccessionsENST00000522726.1
P51512
ENST00000286614.11 [P51512-1]
E5RJA7