MMGT1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MMGT1 at tissue level.

III. Associated gene sets

GO_0006825Biological processcopper ion transport
GO_0045050Biological processprotein insertion into ER membrane by stop-transfer membrane-anchor sequence
GO_0034755Biological processiron ion transmembrane transport
GO_1903830Biological processmagnesium ion transmembrane transport
GO_0015693Biological processmagnesium ion transport
GO_0071816Biological processtail-anchored membrane protein insertion into ER membrane
GO_0006824Biological processcobalt ion transport
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0072546Cellular componentEMC complex
GO_0015093Molecular functionferrous iron transmembrane transporter activity
GO_0022890Molecular functioninorganic cation transmembrane transporter activity
GO_0015095Molecular functionmagnesium ion transmembrane transporter activity
GO_0015087Molecular functioncobalt ion transmembrane transporter activity
GO_0032977Molecular functionmembrane insertase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMMGT1
Protein nameMembrane magnesium transporter
ER membrane protein complex subunit 5 (Membrane magnesium transporter 1) (Transmembrane protein 32)
Membrane magnesium transporter 1
SynonymsTMEM32
EMC5
DescriptionFUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (By similarity). May be involved in Mg(2+) transport (By similarity). .

FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. .

AccessionsENST00000305963.3 [Q8N4V1-1]
ENST00000679621.1 [Q8N4V1-1]
A0A7P0T9E6
ENST00000680510.2
A0A7P0TBL5
ENST00000681201.1
Q8N4V1