MIP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MIP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MIP at tissue level.

III. Associated gene sets

GO_0002088Biological processlens development in camera-type eye
GO_0007601Biological processvisual perception
GO_0006833Biological processwater transport
GO_1990349Biological processgap junction-mediated intercellular transport
GO_0045785Biological processpositive regulation of cell adhesion
GO_0051289Biological processprotein homotetramerization
GO_0055085Biological processtransmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005886Cellular componentplasma membrane
GO_0005921Cellular componentgap junction
GO_0015250Molecular functionwater channel activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding
GO_0005212Molecular functionstructural constituent of eye lens

IV. Literature review

[source]
Gene nameMIP
Protein nameMaFF-interacting protein (Tektin-4 like protein PP5644)
Lens fiber major intrinsic protein (Aquaporin-0)
Lens fiber major intrinsic protein (Aquaporin-0) (MIP26) (MP26)
SynonymsMAFIP
PP5644
AQP0
DescriptionFUNCTION: Water channel . Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling . .

FUNCTION: Acts as a coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency. .

AccessionsA0A140CTY0
Q8WZ33
A0A1B3B2I4
P30301
ENST00000652304.1
A0A1B3B2I6