MICALL2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MICALL2 at tissue level.

III. Associated gene sets

GO_0031175Biological processneuron projection development
GO_0030041Biological processactin filament polymerization
GO_0032456Biological processendocytic recycling
GO_0030036Biological processactin cytoskeleton organization
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0070830Biological processbicellular tight junction assembly
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0005886Cellular componentplasma membrane
GO_0055037Cellular componentrecycling endosome
GO_0043005Cellular componentneuron projection
GO_0005911Cellular componentcell-cell junction
GO_0001725Cellular componentstress fiber
GO_0005829Cellular componentcytosol
GO_0005923Cellular componentbicellular tight junction
GO_0032432Cellular componentactin filament bundle
GO_0031005Molecular functionfilamin binding
GO_0051015Molecular functionactin filament binding
GO_0031267Molecular functionsmall GTPase binding
GO_0046872Molecular functionmetal ion binding
GO_0042805Molecular functionactinin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMICALL2
Protein nameMICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)
SynonymsJRAB
DescriptionFUNCTION: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). .

AccessionsENST00000413446.5 [Q8IY33-2]
ENST00000297508.8 [Q8IY33-1]
Q8IY33