MICAL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051301Biological processcell division
GO_0006887Biological processexocytosis
GO_0007010Biological processcytoskeleton organization
GO_0030042Biological processactin filament depolymerization
GO_0042995Cellular componentcell projection
GO_0090543Cellular componentFlemming body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005886Cellular componentplasma membrane
GO_0005819Cellular componentspindle
GO_0045171Cellular componentintercellular bridge
GO_0005634Cellular componentnucleus
GO_0071949Molecular functionFAD binding
GO_0016709Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO_0003779Molecular functionactin binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameMICAL3
Protein name[F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)
Microtubule associated monooxygenase, calponin and LIM domain containing 3
F-actin monooxygenase (EC 1.14.13.225)
SynonymsKIAA1364
KIAA0819
DescriptionFUNCTION: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. .

AccessionsC9J922
A0A5F9ZHV5
J3KRP8
ENST00000441493.7 [Q7RTP6-1]
J3QLA3
ENST00000584751.1
ENST00000400561.6 [Q7RTP6-4]
ENST00000498573.5
J3QR21
ENST00000672019.1
ENST00000577821.5
ENST00000578984.1
ENST00000579997.5
ENST00000414725.6 [Q7RTP6-3]
J3KSK6
J3QQT0
ENST00000585038.1 [Q7RTP6-5]
ENST00000461307.5
ENST00000424046.1
E9PP85
J3KTB6
ENST00000383094.7 [Q7RTP6-2]
ENST00000495076.5
Q7RTP6