Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 15 studies | 49% ± 18% | |
astrocyte | 14 studies | 31% ± 15% | |
glutamatergic neuron | 13 studies | 56% ± 26% | |
endothelial cell | 13 studies | 37% ± 21% | |
oligodendrocyte precursor cell | 12 studies | 34% ± 14% | |
B cell | 11 studies | 29% ± 7% | |
GABAergic neuron | 10 studies | 57% ± 26% | |
ciliated cell | 8 studies | 24% ± 8% | |
adipocyte | 8 studies | 29% ± 5% | |
smooth muscle cell | 8 studies | 26% ± 8% | |
neuron | 7 studies | 40% ± 16% | |
epithelial cell | 7 studies | 33% ± 16% | |
interneuron | 6 studies | 64% ± 24% | |
naive B cell | 6 studies | 18% ± 2% | |
endothelial cell of lymphatic vessel | 6 studies | 47% ± 10% | |
cardiac muscle cell | 5 studies | 61% ± 14% | |
fibroblast | 5 studies | 20% ± 3% | |
cholangiocyte | 4 studies | 44% ± 24% | |
glial cell | 4 studies | 27% ± 10% | |
granule cell | 4 studies | 53% ± 12% | |
microglial cell | 4 studies | 35% ± 14% | |
Mueller cell | 4 studies | 38% ± 10% | |
GABAergic interneuron | 3 studies | 61% ± 5% | |
macrophage | 3 studies | 30% ± 15% | |
pericyte | 3 studies | 32% ± 19% | |
GABAergic amacrine cell | 3 studies | 30% ± 8% | |
amacrine cell | 3 studies | 27% ± 2% | |
glycinergic amacrine cell | 3 studies | 22% ± 4% | |
retinal ganglion cell | 3 studies | 31% ± 7% | |
abnormal cell | 3 studies | 26% ± 9% | |
hepatocyte | 3 studies | 52% ± 19% | |
ependymal cell | 3 studies | 47% ± 6% | |
lymphocyte | 3 studies | 22% ± 2% | |
basal cell | 3 studies | 32% ± 17% | |
transit amplifying cell | 3 studies | 32% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 8133.00 | 1443 / 1445 | 100% | 7.48 | 183 / 183 |
intestine | 100% | 10989.04 | 966 / 966 | 98% | 4.59 | 518 / 527 |
skin | 100% | 4422.41 | 1806 / 1809 | 98% | 11.74 | 464 / 472 |
brain | 100% | 10587.91 | 2635 / 2642 | 97% | 7.38 | 684 / 705 |
kidney | 100% | 5442.19 | 89 / 89 | 95% | 6.58 | 857 / 901 |
ovary | 100% | 9365.21 | 180 / 180 | 94% | 4.82 | 403 / 430 |
pancreas | 96% | 3028.78 | 316 / 328 | 94% | 2.99 | 167 / 178 |
breast | 100% | 5628.86 | 459 / 459 | 86% | 2.99 | 963 / 1118 |
uterus | 100% | 13001.26 | 170 / 170 | 86% | 3.45 | 394 / 459 |
prostate | 100% | 8367.89 | 244 / 245 | 85% | 3.04 | 429 / 502 |
stomach | 86% | 4240.31 | 310 / 359 | 98% | 5.35 | 280 / 286 |
lung | 98% | 3376.86 | 568 / 578 | 85% | 3.96 | 986 / 1155 |
bladder | 100% | 7866.71 | 21 / 21 | 82% | 2.75 | 413 / 504 |
thymus | 100% | 6758.14 | 652 / 653 | 81% | 2.57 | 489 / 605 |
liver | 100% | 6224.93 | 226 / 226 | 76% | 2.38 | 310 / 406 |
adrenal gland | 100% | 5292.04 | 258 / 258 | 68% | 1.62 | 156 / 230 |
spleen | 100% | 7439.66 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 7750.24 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 5224.82 | 1202 / 1204 | 0% | 0 | 0 / 0 |
heart | 99% | 7820.98 | 850 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 5.58 | 78 / 80 |
lymph node | 0% | 0 | 0 / 0 | 97% | 5.22 | 28 / 29 |
muscle | 96% | 3591.19 | 767 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 3.99 | 41 / 45 |
peripheral blood | 24% | 536.18 | 221 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0051301 | Biological process | cell division |
GO_0006887 | Biological process | exocytosis |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0030042 | Biological process | actin filament depolymerization |
GO_0042995 | Cellular component | cell projection |
GO_0090543 | Cellular component | Flemming body |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005938 | Cellular component | cell cortex |
GO_0005886 | Cellular component | plasma membrane |
GO_0005819 | Cellular component | spindle |
GO_0045171 | Cellular component | intercellular bridge |
GO_0005634 | Cellular component | nucleus |
GO_0071949 | Molecular function | FAD binding |
GO_0016709 | Molecular function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
GO_0003779 | Molecular function | actin binding |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0046872 | Molecular function | metal ion binding |
Gene name | MICAL3 |
Protein name | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) Microtubule associated monooxygenase, calponin and LIM domain containing 3 F-actin monooxygenase (EC 1.14.13.225) |
Synonyms | KIAA1364 KIAA0819 |
Description | FUNCTION: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. . |
Accessions | C9J922 A0A5F9ZHV5 J3KRP8 ENST00000441493.7 [Q7RTP6-1] J3QLA3 ENST00000584751.1 ENST00000400561.6 [Q7RTP6-4] ENST00000498573.5 J3QR21 ENST00000672019.1 ENST00000577821.5 ENST00000578984.1 ENST00000579997.5 ENST00000414725.6 [Q7RTP6-3] J3KSK6 J3QQT0 ENST00000585038.1 [Q7RTP6-5] ENST00000461307.5 ENST00000424046.1 E9PP85 J3KTB6 ENST00000383094.7 [Q7RTP6-2] ENST00000495076.5 Q7RTP6 |