MGAT4B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006486Biological processprotein glycosylation
GO_0006487Biological processprotein N-linked glycosylation
GO_0019082Biological processviral protein processing
GO_0006491Biological processN-glycan processing
GO_0005795Cellular componentGolgi stack
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0008375Molecular functionacetylglucosaminyltransferase activity
GO_0008454Molecular functionalpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameMGAT4B
Protein nameAlpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb) (GlcNAc-T IVb) (GnT-IVb) (N-acetylglucosaminyltransferase IVb) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb)
SynonymsUNQ906/PRO1927
DescriptionFUNCTION: Glycosyltransferase that catalyzes the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains . Prefers complex-type N-glycans over hybrid-types . Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis . .

AccessionsH0YC79
ENST00000638266.2 [Q9UQ53-1]
ENST00000519836.5
H0YB63
H0YC11
E5RFS3
H0YB89
ENST00000518980.5
E5RFL0
ENST00000518778.5
ENST00000523108.5
ENST00000518867.5
H0YB84
ENST00000520918.5
ENST00000520875.5
H0YC13
ENST00000337755.9 [Q9UQ53-3]
ENST00000292591.12 [Q9UQ53-1]
Q9UQ53
ENST00000639538.1 [Q9UQ53-3]
H0YC56
ENST00000520969.5
ENST00000523329.1