Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type II pneumocyte | 12 studies | 45% ± 18% | |
| endothelial cell | 10 studies | 32% ± 11% | |
| epithelial cell | 4 studies | 36% ± 21% | |
| ciliated cell | 4 studies | 19% ± 5% | |
| hepatocyte | 4 studies | 41% ± 10% | |
| Mueller cell | 3 studies | 17% ± 1% | |
| dendritic cell | 3 studies | 19% ± 3% |
Insufficient scRNA-seq data for expression of MFSD2A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 89% | 1470.30 | 2356 / 2642 | 100% | 59.05 | 703 / 705 |
| lung | 75% | 4784.78 | 433 / 578 | 91% | 28.18 | 1047 / 1155 |
| liver | 100% | 12431.67 | 225 / 226 | 50% | 26.99 | 201 / 406 |
| intestine | 56% | 1233.95 | 537 / 966 | 89% | 18.52 | 468 / 527 |
| skin | 85% | 8270.55 | 1529 / 1809 | 53% | 6.73 | 249 / 472 |
| thymus | 60% | 1384.00 | 394 / 653 | 76% | 23.51 | 460 / 605 |
| esophagus | 38% | 658.10 | 546 / 1445 | 93% | 27.23 | 170 / 183 |
| bladder | 24% | 209.14 | 5 / 21 | 94% | 27.64 | 473 / 504 |
| uterus | 21% | 265.93 | 35 / 170 | 88% | 20.98 | 404 / 459 |
| ureter | 0% | 0 | 0 / 0 | 100% | 24.52 | 1 / 1 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 12.79 | 27 / 29 |
| stomach | 6% | 70.22 | 21 / 359 | 80% | 12.66 | 229 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 18.06 | 36 / 45 |
| pancreas | 0% | 2.27 | 1 / 328 | 75% | 15.24 | 134 / 178 |
| breast | 27% | 322.21 | 123 / 459 | 47% | 7.70 | 521 / 1118 |
| kidney | 47% | 619.34 | 42 / 89 | 26% | 3.89 | 233 / 901 |
| ovary | 18% | 182.22 | 32 / 180 | 53% | 7.33 | 229 / 430 |
| peripheral blood | 25% | 290.79 | 230 / 929 | 0% | 0 | 0 / 0 |
| adipose | 23% | 365.60 | 277 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 18% | 302.12 | 44 / 245 | 3% | 0.32 | 16 / 502 |
| adrenal gland | 2% | 10.59 | 4 / 258 | 14% | 1.30 | 33 / 230 |
| heart | 4% | 40.59 | 35 / 861 | 0% | 0 | 0 / 0 |
| spleen | 3% | 32.65 | 8 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.08 | 1 / 80 |
| blood vessel | 1% | 15.17 | 15 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 1% | 6.82 | 5 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0097009 | Biological process | energy homeostasis |
| GO_0031999 | Biological process | negative regulation of fatty acid beta-oxidation |
| GO_0008643 | Biological process | carbohydrate transport |
| GO_0060856 | Biological process | establishment of blood-brain barrier |
| GO_0021766 | Biological process | hippocampus development |
| GO_0035845 | Biological process | photoreceptor cell outer segment organization |
| GO_1990963 | Biological process | establishment of blood-retinal barrier |
| GO_0030307 | Biological process | positive regulation of cell growth |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0015909 | Biological process | long-chain fatty acid transport |
| GO_0003406 | Biological process | retinal pigment epithelium development |
| GO_0008594 | Biological process | photoreceptor cell morphogenesis |
| GO_0061744 | Biological process | motor behavior |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0006656 | Biological process | phosphatidylcholine biosynthetic process |
| GO_1990403 | Biological process | embryonic brain development |
| GO_0150172 | Biological process | regulation of phosphatidylcholine metabolic process |
| GO_0034379 | Biological process | very-low-density lipoprotein particle assembly |
| GO_0040014 | Biological process | regulation of multicellular organism growth |
| GO_0009267 | Biological process | cellular response to starvation |
| GO_0010867 | Biological process | positive regulation of triglyceride biosynthetic process |
| GO_0050773 | Biological process | regulation of dendrite development |
| GO_0150175 | Biological process | regulation of phosphatidylethanolamine metabolic process |
| GO_0140329 | Biological process | lysophospholipid translocation |
| GO_0015908 | Biological process | fatty acid transport |
| GO_0060042 | Biological process | retina morphogenesis in camera-type eye |
| GO_0035633 | Biological process | maintenance of blood-brain barrier |
| GO_0150011 | Biological process | regulation of neuron projection arborization |
| GO_0007420 | Biological process | brain development |
| GO_0045056 | Biological process | transcytosis |
| GO_0050890 | Biological process | cognition |
| GO_1990379 | Biological process | lipid transport across blood-brain barrier |
| GO_0051977 | Biological process | lysophospholipid transport |
| GO_0150178 | Biological process | regulation of phosphatidylserine metabolic process |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0051978 | Molecular function | lysophospholipid:sodium symporter activity |
| GO_0005324 | Molecular function | long-chain fatty acid transmembrane transporter activity |
| GO_0015245 | Molecular function | fatty acid transmembrane transporter activity |
| GO_0005548 | Molecular function | phospholipid transporter activity |
| GO_0140348 | Molecular function | lysophosphatidylcholine flippase activity |
| GO_1901480 | Molecular function | oleate transmembrane transporter activity |
| Gene name | MFSD2A |
| Protein name | MFSD2 lysolipid transporter A, lysophospholipid Sodium-dependent lysophosphatidylcholine symporter 1 (NLS1) (Sodium-dependent LPC symporter 1) (Major facilitator superfamily domain-containing protein 2A) (HsMFSD2A) (MFSD2a) |
| Synonyms | HMFN0656 PP9177 MFSD2 NLS1 UNQ300/PRO341 |
| Description | FUNCTION: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function . Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain . Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation . In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion . . |
| Accessions | Q5SSK0 E7EPI8 ENST00000372809.5 [Q8NA29-1] ENST00000434861.5 Q8NA29 ENST00000372811.10 [Q8NA29-2] ENST00000420632.6 |
