MESP2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MESP2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MESP2 at tissue level.

III. Associated gene sets

GO_0001707Biological processmesoderm formation
GO_0007219Biological processNotch signaling pathway
GO_0003007Biological processheart morphogenesis
GO_0032525Biological processsomite rostral/caudal axis specification
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0046983Molecular functionprotein dimerization activity
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameMESP2
Protein nameMesoderm posterior bHLH transcription factor 2
Mesoderm posterior protein 2 (Class C basic helix-loop-helix protein 6) (bHLHc6)
SynonymsBHLHC6
SCDO2
DescriptionFUNCTION: Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.

AccessionsENST00000341735.5
H0YKZ5
Q0VG99
ENST00000560219.2