MED7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MED7 at tissue level.

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0016567Biological processprotein ubiquitination
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0035019Biological processsomatic stem cell population maintenance
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000151Cellular componentubiquitin ligase complex
GO_0016592Cellular componentmediator complex
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0070847Cellular componentcore mediator complex
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMED7
Protein nameMediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33)
Mediator of RNA polymerase II transcription subunit 7
SynonymsARC34
CRSP9
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

AccessionsENST00000420343.1
O43513
ENST00000524289.1
ENST00000286317.6
E5RIE8